Are you
a Start-Up?
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Vision: Do you know where your process is headed? Don’t look back and regret earlier decisions – realizing avoidance was possible if only someone had pointed out the now obvious.​
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Scale-Up: Moving to the next level does not have to be nerve racking. Know the pitfalls that exist and plan appropriately. I am always amazed at the highly opinionated who have done very little scale-up. There are a few important items, and many that are less important. Know the difference.
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Modeling: Don’t feel bad. I am amazed at the number of companies that put this off. You need a good Techno-Economic Analysis (TEA). What happens if the fermentor is 50m 3 bigger? What’s better: sterilize the fermentor in batch or continuous mode? Any clue just how much water your process uses? Also, a well constructed TEA will feed right into an LCA model.
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​Production Location: Engage a CRO now and build later? Let’s discuss production options based on your current and planned process phase.
Is Production Underway?
Need more Product!
Production improvement should be an annual goal – without the addition of more stainless steel. I have designed dozens of processes. Let’s make sure you are not overlooking an easy improvement.
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Need to Scale-down?
Yes! Many times I’ve had to step back to move forward. You need a good lab model that predicts the impact of production changes. The model does not need to match exactly, but it must be predictive. Know the difference.
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Where to Manufacture?
Running out of production space? Let’s discuss options.
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Technology Selection
Which DO/pH/FTIR probe technology is best? Is single-use really worth the cost? Is on-line analysis even practical for my process?
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Contamination Control
Let’s face it: like other things in life, contamination happens. Truth is, it should be a rare event.
Learn how to methodically shake down your process and eliminate bad practice and faulty systems. Stop wasting money.
VC and PE:
Buyer Beware:
I’ve heard too many horror stories regarding disappointment after
closing. Let me shake down their claims and give you an outside assessment. The sales pitch is always rosy.
Let’s examine:
-The technology
-Unresolved and future possible issues
-Technical capability (Does it exist? Is it too dependent on a few folks?)
-IP positioning (How much protection does the patent really provide? I’ve worked around many a “restrictive” patent.)
